Anteromedial nucleus’s afferent input include the medial mammillary bodies, rostral dorsal reticular nucleus, prelimbic and medial orbital cortices, anterior cingulate and dysgranular retrosplenial cortex, secondary motor cortices, entorhinal cortex, and subiculum. It projects to frontal area 2, frontal polar and medial orbital cortex, anterior cingulate cortex, dysgranular retrosplenial cortex, entorhinal cortex, perirhinal cortex, presubiculum, subiculum, visual cortex area 18 b, temporal area 2, occipital area 1 and 2, and (medial) secondary motor cortices.  It is primarily a feed-forward system that conveys integrated hippocampal-diencephalic information to prefrontal cortex, regulating executive function and higher-order cognition.